sesamin Herb Source
Sesamum indicum L. Zanthoxylum acanthapodium var. villosum Huang. Piper longum
sesamin Molecular Formula and Molecular Weight
C20H15O6
351.34
sesamin Melting Point
122 -123
sesamin Solubility
sesamin Freely soluble in chloroform-benzene-acetic acid and acetone.
sesamin Pharmacology
Antioxidant Bactericide Insecticide Non-competitive D5-desaturase inhibitor.
Sesamin is an all-natural component stored in sesame seeds. Its content is only about 0.5 percent. Through extracting sesamin from sesame, and experimenting in animals and humans, the Japanese scientific researchers have discovered that sesamin has effects of preventing hypertension and cardiovascular hypertrophy, protecting liver, resisting oxidation, reducing cholesterol, and anti-cancer .
Effect of sesamin, a sesame lignan, on the hepatic fatty acid metabolism was examined in the rat.
Increase of the dietary level of sesamin progressively increased the mitochondrial and peroxisomal
fatty acid oxidation rate. Mitochondrial activity almost doubled in rats fed a 0.5% sesamin diet. Peroxisomal
activity became more than 10 times higher in rats fed a 0.5% sesamin diet, co***red to those
fed a sesamin-free diet. Dietary sesamin also markedly increased the hepatic activity and mRNA levels
of various fatty acid oxidation enzymes. In contrast, dietary sesamin decreased the hepatic activity
and mRNA abundance of lipogenic enzymes. This was associated with the down-regulation of sterol
regulatory element-binding protein-1, a transcriptional factor that regulates the lipogenic enzyme gene
expression. Dietary sesamin significantly decreased the triacylglycerol secretion acco***nying the
increase in ketone body production by the perfused rat liver. It is apparent that sesamin affects the fatty
acid metabolism and lipoprotein production in the liver, and hence lowers the serum lipid levels. We
also developed several sesame lines with seeds containing sesamin and sesamolin at twice the concentration
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